منابع مشابه
Development of an Alternative Modified Live Influenza B Virus Vaccine
Influenza B virus (IBV) is considered a major human pathogen, responsible for seasonal epidemics of acute respiratory illness. Two antigenically distinct IBV hemagglutinin (HA) lineages cocirculate worldwide with little cross-reactivity. Live attenuated influenza virus (LAIV) vaccines have been shown to provide better cross-protective immune responses than inactivated vaccines by eliciting loca...
متن کاملInfluenza B virus NS1-truncated mutants: live-attenuated vaccine approach.
Type B influenza viruses can cause substantial morbidity and mortality in the population, and vaccination remains by far the best means of protection against infections with these viruses. Here, we report the construction of mutant influenza B viruses for potential use as improved live-virus vaccine candidates. Employing reverse genetics, we altered the NS1 gene, which encodes a type I interfer...
متن کاملLive attenuated influenza vaccine--a review.
Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered "sub-optimal". Many studies have been carried out in recent years to improve vaccines. In particular, researchers and vaccine-producing corporations have focused on developing a live vaccine. Among the candidate vaccines,...
متن کاملAcceptability of intranasal live attenuated influenza vaccine, influenza knowledge and vaccine intent in The Gambia
BACKGROUND The burden of influenza is increasingly recognised in Africa. The WHO recommends introducing influenza vaccination to high-risk groups: pregnant women, children <5 years, and the elderly. The Gambia currently has no influenza vaccination policy, but the NASIMMUNE study, a clinical trial of intranasal live attenuated influenza vaccines (LAIV) in young children provided an opportunity ...
متن کاملLive Attenuated Influenza Vaccine in Children Induces B-Cell Responses in Tonsils
BACKGROUND Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely report the mucosal humoral responses in tonsils and saliva after intranasal live attenuated influenza vaccine (LAIV) vaccination in children. METHODS Blood, saliva, and tonsils ...
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ژورنال
عنوان ژورنال: Journal of Hygiene
سال: 1969
ISSN: 0022-1724
DOI: 10.1017/s002217240004136x